Adaptive Deep Brain Stimulation

Using implanted bidirectional sensing and stimulation devices covering the motor cortex and basal ganglia, our study aims to determine the neural biomarkers of gait, and design personalized adaptive deep brain stimulation programs to dynamically alter stimulation based on phases of the gait cycle.

Featured Publications

Louie KH, Gilron R, Yaroshinsky MS, Morrison MA, Choi J, de Hemptinne C, Little S, Starr PA, Wang DD. Cortico-Subthalamic Field Potentials Support Classification of the Natural Gait Cycle in Parkinson's Disease and Reveal Individualized Spectral Signatures. eNeuro. 2022 Nov 11;9(6):ENEURO.0325-22.2022. doi: 10.1523/ENEURO.0325-22.2022.

Gilron R, Little S, Perrone R, Wilt R, de Hemptinne C, Yaroshinsky MS, Racine CA, Wang SS, Ostrem JL, Larosn PS, Wang DD, Galifianakis NB, Bledsoe I, San Luciano M, Dawes HE, Worell GA, Kremen V, Borton D, Denison T, and Starr PA. Chronic wireless streaming of invasive neural recordings at home for circuit discovery and adaptive stimulation. Nature Biotech. 2021 May 3. doi: 10.1038/s41587-021-00897-5. Online ahead of print. PMID: 33941932.

Wang DD, Choi JT. Brain Network Oscillations During Gait in Parkinson's Disease. Front Hum Neurosci. 2020 Oct 23;14:568703. doi: 10.3389/fnhum.2020.568703.

Tamir I, Wang D, Chen W, Ostrem JL, Starr PA, and de Hemptinne C. Eight cylindrical contact lead recordings in the Subthalamic region localize beta oscillations source to the dorsal STN. Neurobio Dis. 2020 Sept 23. doi: 10.1016/j.nbd.2020.105090. PMID: 32977021.

de Hemptinne C*, Wang DD*, Miocinovic S, Chen W, Ostrem JL, Starr PA. Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson’s disease. Mov Disord. 2019 June; 34(6): 903-911. doi:10.1002/mds.27658. Epub 2019 Mar 13. PMID: 30868646. *contributed equally

Wang DD, de Hemptinne C, Miocinovic S, Ostrem JL, Galifianakis NB, San Luciano M, Starr PA. Pallidal deep brain stimulation disrupts pallidal beta oscillations and coherence with primary motor cortex in Parkinson’s disease. J. Neurosci. 2018 May 9; 38(19):4556-4568. PMID: 29661966.

Wang DD, de Hemptinne C, Miocinovic S, Qasim SE, Miller AM, Ostrem JL, Galifianakis NB, San Luciano M, Starr PA. Subthalamic local field potentials in Parkinson’s disease and isolated dystonia: An evaluation of potential biomarkers. Neurobio Dis. 2016 May; 89:213-22. PMID: 26884091.